Received: MaAccepted: MaPublished: April 5, 2019Д¬opyright: В© 2019 Abed et al. PLoS ONE 14(4):Д®ditor: Edward William Harhaj, Johns Hopkins School of Medicine, UNITED STATES (2019) The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification. Expression of Hbegf was reduced in PEG10-deficient TSCs suggesting that PEG10 might bind to and stabilize RNAs that are critical for normal placental development.Д¬itation: Abed M, Verschueren E, Budayeva H, Liu P, Kirkpatrick DS, Reja R, et al. PEG10 expressed in wild-type, differentiating TSCs was bound to many cellular RNAs including Hbegf (Heparin-binding EGF-like growth factor), which is known to play an important role in placentation. Consistent with PEG10 having a critical role in placental development, PEG10-deficient trophoblast stem cells (TSCs) exhibited impaired differentiation into placental lineages. Expressed in a subset of mouse endocrine organs in addition to the placenta, PEG10 was identified as a substrate of the deubiquitinating enzyme USP9X. Here we show that the Gag domain of PEG10 can promote vesicle budding similar to the HIV p24 Gag protein. It is thought to derive from a Tењ“-gyspy LTR (long terminal repeat) retrotransposon and retains Gag and Pol-like domains. Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental development.

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